Preclinical validation of the tissue adhesive patch via in vivo animal models
Project Abstract:
The objective of this proposal is to adapt a novel tissue adhesive patch for specific thoracic surgery applications Despite being standard of care the surgical closure of defects in the tracheal and bronchial airways of the lung by sutures and staples is limited by up to 30 failure rate due to partial tissue breakdown or technical aspects Anastomotic and closure failures causing leaks are feared complications as they can lead to lifethreatening fistulae bleeding and sepsis and thus significantly increase patient mortality To date there is no strong evidence supporting the use of available tissue adhesives and glues that reinforce closures and reduce lake rate as those simply lack clinical efficacy Leveraging our strong preliminary results invitro and in rat models and multidisciplinary expertise we propose to develop customized tissue adhesive patches to address unmet clinical needs for various thoracic surgery indications i To form instant adhesion on wet body fluidcovered thoracic tissues and organs ii To provide strong and stable adhesion with reliable airfluidtight sealing over the long term and iii To provide easy and reproducible usage and performance in minimally invasive surgical setups This proposed project will take these products to preclinical testing in a large animal model that could rapidly migrate to FDA approval for first in human trials It is likely that if found efficacious for thoracic surgery applications the adhesive patches could prove to be a significant advancement in the field of surgery in general with farreaching benefits for patients and the health care system
