Prepare Your Application
When ready, access the application forms and prepare your application using ASSIST—NIH’s online application preparation and submission system used by ~75% of HHS small business applicants. eRA Commons credentials are required to use ASSIST.
You can also apply using Grants.gov Workspace or a system-to-system solution; there are no options to download and mail forms to NIH.
- Prepare your application using ASSIST and learn how to handle systems issues.
- Explore annotated form sets and system-enforced business rules (referred to as validations) and gain tips for avoiding common errors.
- Using human subjects? Watch this Human Subjects Research: What SBIR & STTR Applicants Need to Know webinar and review the Human Subjects System Warning and Error Quick Guide.
- Learn how to write a strong application with general tips and advice from NIH and planning and writing advice from the NIH Center for Scientific Review.
- Applying for STTR funding? Review the STTR Model Agreement for the Allocation of Rights. This form is not submitted with an application but must be furnished upon request of the NIH awarding component.
- Aging (NIA) Sample Applications
- Allergy and Infectious Diseases (NIAID) Sample Applications
- Cancer (NCI) Sample Applications
First-time applicant? Learn about the free NIH Applicant Assistance Program, a 10-week coaching and customized program for first-time small business applicants.
The National Institute on Minority Health and Health Disparities has a free Health Disparities Pre Application (HDPreApp) Program that aims to improve an application's scientific merit and commercialization plan.
There's also a free NIAID Applicant Assistance Program for companies planning to apply for National Institute of Allergy and Infectious Diseases (NIAID) Phase I, Phase II/IIB, Fast Track, or Direct to Phase II SBIR or STTR funding.
Looking for additional resources and support? The Small Business Administration funds support programs in most states and Puerto Rico through its Federal and State Technology (FAST) Partnership Program. Find the state organization in your area and learn how they can help you apply for SBIR or STTR funding.
Financial support from the NIH as part of their SBIR program was very much a critical component to the early start of this company [and] it continues to be a component of our success.
The NIH SBIR program has been invaluable. There'd be no other way that this would have been an option to provide to the autism community.
Litron Laboratories’ rate of innovation would not be possible without the benefit of SBIR funding.
The SBIR program is significantly important for disseminating, not just information, but actual interventions, especially for underrepresented populations.
[NIH small business funding] gave us the preliminary data that allowed us to approach investors and Big Pharma to fund the amount needed to move into phase two and phase three.
The grant gave us the funding to hire curriculum writers, to pay teachers to do pilot testing of the kits, and to go to science education conferences and present the kits; it gave us money to pay stipends for teachers who wanted to hold their own workshops, and money to provide the kits for the workshop. It really allowed the company to grow much more dramatically.
[SBIR] funding was absolutely critical to getting us off the ground.
Our very first funding came from the NIH. The origins of our success came from an NIH-funded project, and since then, we have been able to build on and expand our knowledge and tackle other pollutants.
We’re staunch supporters of this program. If anyone asks me about the NIH Small Business program, I give them nothing but encouragement to apply.
In terms of venture capitalists for minority businesses, it is a really unfair playing field. So, the fact that SBIR funds minority businesses like ours is huge because otherwise, we would not get any investments.
This funding allowed me to achieve a scientific breakthrough and now I can talk about early detection, and I can talk about cancer, fibrosis, and changing the industry.